Other pro-apoptotic genes that were found upregulated upon PVT1 knockdown were BMF, which encodes a pro-apoptotic BCL2-family protein [59], IFIT2, which triggers apoptosis through a BCL2-dependent mitochondrial pathway [60], TNFRSF21, an apoptosis activator gene in bladder cancer [61], and HRK, which encodes a pro-apoptotic protein that interacts with BCL2 and Bcl-XL apoptosis-repressor proteins [62]. The gene discussed is HRK; the disease is urinary bladder carcinoma.