EZH2 and cancer: PVT1 has been described in other types of cancer to act in the nucleus; thus, in ovarian cancer PVT1 represses miR-214 expression by recruiting EZH2 to its promoter [25], and in non-small cell lung cancer (NSCLC) PVT1 inhibits the expression of Large Tumor Suppressor Kinase 2 (LATS2) by recruiting EZH2 to the LATS2 promoter [26].