PVT1 and Familial prostate cancer: Also, we detected an inverse correlation in the TCGA-PRAD tumors between the expression of PVT1 and the expression of the 121-gene-set (out of the 160 genes that were repressed by androgen and de-repressed by PVT1 knockdown in LNCaP cells), which points to the relevance of further characterizing the interaction between PVT1 and tumor suppressor genes in determining an aggressive phenotype in prostate cancer.