PVT1 and cancer: “Cell proliferation” was one of the top most significantly enriched GO categories among the 396 upregulated genes (Additional file 2: Fig. S3b), also including “Positive regulation of cell cycle arrest”; this again suggests that endogenous PVT1 in LNCaP cancer cells might repress the expression of genes related to cell cycle arrest and favor cell proliferation, even under hormone starvation.