FOXO3 and Familial prostate cancer: Kong et al. reported the upregulation of circFOXO3 (hsa_circ_0006404), which was derived from exon 2 of the forkhead box O3 (FOXO3) gene, in serum from patients with prostate cancer; circFOXO3 exhibited oncogenic activity by altering the cell cycle and apoptosis in the process of sponging miR-29a-3p to regulate SLC25A15 expression [33].