MYC and acute myeloid leukemia: In contrast, one recent study demonstrated that high METTL14 expression is present in normal hematopoietic stem/progenitor cells (HSPCs) and acute myelogenous leukemia (AML) cells with t(11q23), t(15;17) or t(8;21) translocation, and suppresses terminal myeloid differentiation and promotes leukemogenesis by positively regulating expression of MYB and MYC through m6A-based post-transcriptional regulation [28].