Given the results of correlation analysis based on TCGA cohort, METTL14 and YTHDC1 were the two most relevant m6A regulatory genes (Pearson’s r = 0.66), which indicated that the process of RNA m6A modification in ccRCC may be the result of combined action by m6A writer gene (METTL14) and reader gene (YTHDC1). This evidence concerns the gene YTHDC1 and nonpapillary renal cell carcinoma.