In order to explore how METTL14 was involved in ccRCC pathogenesis, we carried out GSEA between tissues with different METTL14 expression levels and found that high METTL14 expression was associated with some essential signaling pathways including ERBB pathway, MAPK pathway, mTOR pathway, renal cell carcinoma, pathway in cancer, TGF-β pathway and Wnt pathway. The gene discussed is METTL14; the disease is hereditary clear cell renal cell carcinoma.