As we all know, epidermal growth factor receptor (EGFR), as known as ErbB1, plays vital roles in enhancing tumor cell proliferation, suppressing apoptosis and contributing to the development and metastasis of renal cell carcinoma [30–32], and translation of EGFR has been recently found to be promoted by METTL3 in cancer cells [19]. This evidence concerns the gene METTL3 and hereditary clear cell renal cell carcinoma.