Three different breast cancer cell morphology was examined and the result showed that in the cell lines with high TIMELESS expression, the cells were mainly epithelioid morphology (Fig. 1a, b), while in ZR-75-30 cell line, the expression of TIMELESS was lower than the other two, and the cell morphology was mesenchymal-like (Fig. 1a, b). The gene discussed is TIMELESS; the disease is breast cancer.