Using the genome-wide genotyping approach this study identified ten novel associations with T2DM complications, including GYPA (rs1132787) in diabetic neuropathy, PDE4DIP (rs2477088), NAT8 (rs4852954), F5 (rs6032), RPS6KA2 (rs6935464) in macrovascular complications, and CCDC146 (rs3095447) in ophthalmic complications. The gene discussed is PDE4DIP; the disease is diabetic neuropathy.