Using the genome-wide genotyping approach this study identified ten novel associations with T2DM complications, including GYPA (rs1132787) in diabetic neuropathy, PDE4DIP (rs2477088), NAT8 (rs4852954), F5 (rs6032), RPS6KA2 (rs6935464) in macrovascular complications, and CCDC146 (rs3095447) in ophthalmic complications. This evidence concerns the gene F5 and type 2 diabetes mellitus.