PDE4DIP and type 2 diabetes mellitus: Although the rs2477088 variant has not been previously linked to any T2DM manifestations, PDE4DIP, also known as myomegalin or cardiomyopathy-associated protein 2, is a well-known contributor of the microtubule control process [36] and some previous evidence exist indicating on the potential role of the gene in macrovascular diseases and T2DM.