A genome-wide association study suggested that increased European ancestry in non-European population might be associated with the occurrence of glioma and identified four novel susceptibility variants, including 7q21.11 (SEMA3A), 11p11.12 (Intergenic), 12q24.21 (RBM19) and 20p12.13 (HAO1, BMP2) [23]. Here, SEMA3A is linked to central nervous system cancer.