In our study, the combination of MMSE and MoCA has confirmed MCI in SPG11-related HSP-TCC, characteristically presenting potential deficits in multiple cognitive domains that were not detected by the MMSE, including executive function and abstraction (not tested by the MMSE) and delayed recall and language repetition (MMSE items too easy). The gene discussed is SPG11; the disease is hereditary spastic paraplegia.