Case 1 was diagnosed as Dent disease 1 with a CLCN5 pathogenic variant, Case 2 was diagnosed as Dent disease 2 carrying the pathogenic variant in the OCRL gene (initially diagnosed with Fanconi syndrome according to clinical manifestations), and Case 3 was consistent with Fanconi syndrome caused by hepatocyte nuclear factor 4α (HNF4A) pathogenic variant. The gene discussed is OCRL; the disease is Dent disease.