TP53 and colorectal cancer: Interestingly, FA is a causative agent of esophageal cancer12 and decreases p53 expression;13 on the other hand, FA has activity against head and neck squamous cell carcinoma14,15 and human esophageal epithelial carcinoma cells.16 Therefore, the SNV profiles indicate that the effect of FA on human colorectal cancer cells should be further investigated.