Therefore, cells with high SLC7A11 levels are expected to be resistant, while those with low SLC7A11 expression to be sensitive to APR246, indicating SLC7A11 as a response predictor, as demonstrated in cells from the esophageal carcinoma and in cells from the NCI-60 cell lines panel, representing different solid and hematological malignancies [88]. The gene discussed is SLC7A11; the disease is hematologic disorder.