APR246 displayed significant cytotoxicity in primary MM cell samples with TP53 locus deletion and in several cell lines with P53 alterations representative of the heterogeneity of those occurring in MM [i.e., del(17p), point mutations, exon deletions] by increasing intracellular ROS and depleting the GSH level [80]. The gene discussed is TP53; the disease is Miyoshi myopathy.