In this study, APR246 efficiently induced cell death by apoptosis in both wild-type and mutant P53 bearing CLL cells; interestingly, in some samples with an accumulation of mutant P53 protein, APR246 significantly reduced P53 level, which correlated with lower viability and a more efficient apoptosis induction compared to samples carrying a stable mutant P53 [92]. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.