Autophagy was induced by PRIMA-1 in breast and colon cancer cells bearing both mutant and wild-type P53 as well as in their derivative P53-null cells; however, after treatment, a decrease of mutant but not of wild-type P53 protein was observed, suggesting that a protein degradation pathway, likely autophagy-related, acted specifically on mutant P53 protein [90]. The gene discussed is TP53; the disease is colonic neoplasm.