Conversely, it was shown that IFN-β1 over-expression as well as IFN-α-2b administration in mouse models of HFD-induced obesity prevent weight gain and suppress immune cell infiltration into AT, attenuate adipose inflammation and limit AT expansion [87], or increase fatty acid oxidation and reduce cholesterol levels [88], respectively. The gene discussed is IFNA2; the disease is obesity due to melanocortin 4 receptor deficiency.