In the sub-analysis by health status, we found that the four parameters evaluated improve significantly after the administration of RV in subjects with T2DM (effect size on glucose = −13.36 mg/dL, p = 0.0007; effect size on insulin = −0.94 mIU/L, p = 0.007; effect size on HbA1c = −0.22%, p = 0.02; effect size of HOMA-IR = −0.83, p = 0.04). The gene discussed is INS; the disease is type 2 diabetes mellitus.