The study of Grasso et al. [81] demonstrated that treatment with the pan-HDAC inhibitor, Panobinostat in combination with the histone demethylase inhibitor GSKJ4 increased H3 acetylation and H3K27 methylation, reversing partially the H3.3 K27M global hypomethylation phenotype in diffuse intrinsic pontine gliomas (DIPG) bearing the H3.3 K27M mutation. The gene discussed is HDAC9; the disease is diffuse intrinsic pontine glioma.