In another study by Hashizume et al. [83], inhibition of the H3K27 demethylase, Jumonji Domain Containing 3, Histone Lysine Demethylase (JMJD3) in pediatric high-grade gliomas (HGG) using GSKJ4 exhibited a 50% decrease in growth, increased apoptosis, and inhibition of clonal growth of H3.3 K27M glioma cells in vitro. This evidence concerns the gene KDM6B and malignant glioma.