However, bivalent regions are also adjacent to active genes which are cancer-protective in PN tumors, such as Intercellular Adhesion Molecule 5 (ICAM5), an intracellular adhesion molecule, regulating interactions between neurons and microglia, Slit Guidance Ligand 2 (SLIT2), which guides the axons of the developing forebrain and is associated with better survival in glioma patients [53]. This evidence concerns the gene SLIT2 and central nervous system cancer.