CD274 and neoplasm: Specifically, following one line of investigation of our group and our previous results [15,58], we intend to combine MLo1302 both with histone deacetylase inhibitors (HDACis) Belinostat and Panobinostat (to assess synergy with hypomethylating properties of MLo1302) and also with anti-PD1/PDL1 agents (to assess the potential for epigenetic activation of tumor microenvironment and enhance response to immunotherapies).