TWIST1 and glioblastoma: For example, in glioblastoma (and possibly other tumor types), the glycoprotein Epsin3 (EPN3) may be related to Notch and WNT/β-catenin signaling pathways, and helps to induce EMT in glioblastoma cells after activating SLUG, TWIST, and ZEB1, but not Snail1 or ZEB2.