TP53 and neoplasm: The additional HPV oncogenes like E6 and E7, with their potent modification of the retinoblastoma (Rb) and p53 (TP53) regulation of the cell cycle progression, may disrupt or modulate the tumor-suppressive activities of Notch signaling, and vice versa; links between Notch and target genes like Cyclin D1 and MDM2 may also contribute to these net effects, as has been outlined above.