Blocking of ligand activation of Notch (all receptors) by using a soluble Notch4 exodomain (XNotch4) in BrCa xenografts promoted apoptosis and reduced tumor size and metastasis concomitantly to SNAI2 expression reduction, CDH1 upregulation, and active β-catenin suppression [147]. The gene discussed is CDH1; the disease is neoplasm.