Activated caspase-1 and caspase-11/4/5 cleave gasdermin D (GSDMD) in inflammatory cells, while caspase-3 cleaves gasdermin E (GSDME) in tumor cells [58], to release the N terminal domain of gasdermins that inserts into the plasma membrane to form pores that allow intracellular molecules to pass through. Here, GSDME is linked to neoplasm.