We further investigated the potential distinct features between the IFNγ− versus IFNγ+ subgroups of CRC in terms of TIL density and secreted cytokines, as well as immunomodulatory factors such as PD1, IL-10, and Transforming Growth Factor beta 1 (TGFβ1), known to suppress the IFNγ response. This evidence concerns the gene TGFB1 and colorectal carcinoma.