The “heterogeneous low” pattern included CRC with an IL-18 staining intensity lower in tumor cells than in the paired normal epithelial cells (10/192 = 5%) and CRC with an IL-18 staining intensity equal to that of paired normal epithelial cells in 10–49% of tumor cells (43/192 = 22%) (Figure 1A, upper panel). This evidence concerns the gene IL18 and neoplasm.