CD8A and neoplasm: First, we used the Gower metric to assess the similarity/dissimilarity between CRCs according to the following mixed variables (both categorical and numerical): microsatellite status (MSS, MSI), aCasp1 status in tumor cells (present (+) or not (−)), levels of mature IL-18 and of IFNγ secreted in explant cultures, and density of TILs (CD8/CD3, Tbet/CD3, PD1/CD3 ratios).