IFNG and neoplasm: Figure 4B shows the three different clusters: cluster 1, featuring an MSS phenotype with aCasp1− tumor cells (n = 28; 29%); cluster 2, featuring an MSS phenotype with aCasp1+ tumor cells (n = 47; 49%), and cluster 3, featuring mainly an MSI phenotype with aCasp1+ tumor cells (n = 16; 17%) and only five MSI cases with aCasp1−. The CRCs without IFNγ response (IFNγ− red dots on Figure 4B) were more common in cluster 1 (36%, MSS aCasp1−) and cluster 3 (50%, MSI), than in cluster 2 (25%, MSS aCasp1+). Similar results were obtained using hierarchical clustering (Figure S1).