To our knowledge, our findings are the first to show the presence of two subgroups of CRC: a minor subgroup devoid of active caspase-1 (aCasp1−) in tumor cells (an expression profile close to that of normal colonic epithelial cells), and a major subgroup with aberrantly active caspase-1 in tumor cells (aCasp1+). Here, CASP1 is linked to neoplasm.