MYC and anaplastic large cell lymphoma: Lastly, since we previously found that MYC is a key regulator of the RU/RR dichotomy, with MYC being more highly expressed in RR cells [29,31,32], we assessed if experimental manipulation of the MYC expression level can significantly modulate the autophagy response in ALK + ALCL, and thus their sensitivity to crizotinib.