However, MSI demonstrated a complete absence of CD8+ and FOXP3+ T cells within a radius of 10 μm and a highly significant lower frequency of MUM1p+CD3− B/plasma cells within a radius of <50 μm to CD34+ HSPC in control samples, while in MDS/sAML BMB, these cells were regularly detected in these localizations. This evidence concerns the gene FOXP3 and myelodysplastic syndrome.