Indeed, not only both SARS-CoV-1 and SARS- CoV-2 Orf9b localized to the mitochondria both when overexpressed after transient transfection and in the context of physiological viral infection, but after transfection in HeLa cells they co-localized with Tom70 and the authors also observed a decrease in Tom70 expression after viral infection, already suggesting a potential mechanism of the virus to escape antiviral response. Here, TOMM70 is linked to viral infectious disease.