Finally, during infection the authors observed a significant regulation of phosphatidylinositol enzyme activities for PIK3CA, PLCB3 and PIKFYVE; in fact, apilimod (a PIKFYVE inhibitor) showed strong antiviral activity (Table 2) and the authors attributed this finding to a mechanism of regulation by phosphorylation of PIKFYVE upon viral infection. The gene discussed is PIKFYVE; the disease is viral infectious disease.