A screen through a cancer genome database together with functional studies revealed several constitutively active Orai1 single-point mutants (Orai1 H134A, Orai1 A137V, Orai1 L138F, and Orai1 M139V) in TM2 that appear in various human cancers, such as colorectal adenocarcinoma or stomach carcinoma [44]. The gene discussed is ORAI1; the disease is cancer.