Comparison of next-generation sequencing of high-grade UUT cancer with high-grade UC of the bladder identified similar pathogenic germline variants in both cancer types, but at different frequencies [76], confirming a higher prevalence of fibroblast growth factor receptor 3 (FGFR3), HRAS and CDKN2B mutated genes in high-grade UUT cancers, and TP53 and RB1 in high-grade UC of the bladder [76,77]. This evidence concerns the gene RB1 and cancer.