CNAs were observed in 84% of patients, with a gain in copy number for SOX2, MYC, NFIB and CD274 and losses for CNTN3, FHIT, RASSF1, RB1 and KIF2A, showing significant differences between LD-SCLC and ED-SCLC. The gene discussed is RB1; the disease is small cell lung carcinoma.