These subtypes are the neuroendocrine subtypes SCLC-A (ASCL1-positive) and SCLC-N (NEUROD1-positive) and the non-neuroendocrine subtypes SCLC-P (POU2F3-positive) and SCLC-Y (YAP1-positive) [25]. This evidence concerns the gene ASCL1 and small cell lung carcinoma.