In addition to the role of the whole RD1 genomic segment in protective immunity [172,173], the evaluations of individual RD1 proteins for vaccine development in animals have shown the potential of PE35, PPE68, ESAT6, and CFP10 in the development of new subunit vaccines for TB [174,175,176,177,178,179,180,181]. The gene discussed is PDE6B; the disease is tuberculosis.