In advanced CRCs, tumor cell proliferation can be promoted by CAFs which express hydrogen peroxide-inducible clone-5 (HIC-5) [109] or Snail-1 [110], or CAFs which secrete FGF-1, FGF-3 [111], or exosomal circular RNA SLC7A6 [112]. Here, TGFB1I1 is linked to neoplasm.