Another example of a “multifunctional subset” includes Wnt2-expressing CAFs, which can promote CRC cell proliferation and migration [114,115], facilitate CRC invasion via ECM remodeling [115], and increase tumor angiogenesis by secreting several pro-angiogenic factors (e.g., angiopoietin-2 (ANG2), placental growth factor (PGF)) [116]. Here, PGF is linked to neoplasm.