Similar results were observed in the AOM/DSS model upon fibroblast-specific (COL1A2-driven Cre expression) loss of inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ) [36] and loss of tumor progression locus 2 (TPL2) in myofibroblasts (COL6-Cre) [37]. This evidence concerns the gene MAP3K8 and infectious otitis media.