The role of regulating HIF in cisplatin-induced nephrotoxicity is summarized in Table 1; besides the evidence that HIF accumulation by PHD inhibitors treatment protects against cisplatin-induced nephrotoxicity [18], studies have reported beneficial effects of PHD inhibitors in other kidney diseases including ischemic AKI [167,168], diabetic nephropathy [182,183], obesity related kidney disease [181], chronic tubulointerstitial nephritis [184], and remnant kidneys models of CKD [186]. This evidence concerns the gene PDC and chronic kidney disease.