A CAF-derived cytokine, CXCL12, interacts with CXCR4 (C-X-C-motif chemokine receptor 4), a protein overexpressed on the surface of cancer cells, whose interplay leads to the induction of the tumor angiogenesis through endothelial cell recruitment into the tumor niche (Figure 3). The gene discussed is CXCL12; the disease is neoplasm.