It also induced the secretion of metastasis-inducing CXCL1 (C-X-C- motif chemokine 1) and CXCL8 (C-X-C- motif chemokine 8) in melanoma cells, while in vivo studies indicated a correlation between End-1 level and melanoma invasiveness [37,38,39,40]. Here, VPS11 is linked to melanoma.