TP53 and breast carcinoma: For that reason, we focused on determining the total protein expression levels of the intrinsic mitochondrial pathway-related proteins and the extrinsic death receptor pathway-associated proteins through Western blot analysis in RKO cells (colon cancer cells with BRAF V600E mutation, p53 wild type) and in MDA-MB-468 cells (breast cancer cells with homozygous p53 mutation R273H) that had been pretreated with (0.5–1.75 mM) BAT or (100–200 mM) Tau for 48 h.