In a population-based prospective cohort study involving 6408 participants, 59.2% women, polymorphisms c.454-397T>C and c.454-351A>G were observed in the ESR1, with the possibility of four haplotype alleles and during a seven-year follow-up, 285 patients had MI and 440 had ischemic heart disease. This evidence concerns the gene ESR1 and coronary artery disorder.