In addition, overexpression of ERβ led to improved survival, attenuated ventricular dilatation and hypertrophy, and improved cardiac function after MI in mice of both sexes, probably as a consequence of higher content of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2a and reduced expression of collagens I and III, periostin and miR-21 [90]. The gene discussed is ESR2; the disease is myocardial infarction.