Complementing the beneficial cardiac action of this receptor, GPER activation also regulates myocardial Ca2+ dynamics, left ventricular pressure, and the frequency of ectopic contractions in isoproterenol-induced MI model in female rats and prevents potentiation of peak currents through L-type Ca2+ channels in cardiomyocytes [95]. The gene discussed is GPER1; the disease is myocardial infarction.