CD8A and infection: It has long been recognized that amplification of high-affinity TCR clonotypes in antiviral CD8+ T cells is associated with the control of chronic viral infections, as shown for instance in animal models of infection by vaccinia virus, herpes simplex virus-1, equine infectious anemia virus, paramyxovirus simian virus-5, and respiratory syncytial virus (RSV) [124,125,126].