Li et al. underpinned the role of TRPV4/Ca2+ signalling-promoted endometrial cancer metastasis through the modulation of the cytoskeleton in a mechanism involving the activation of the RhoA (Ras homolog gene family member A)/ROCK1(Rho-associated protein kinase 1) signalling pathway [109]. The gene discussed is ROCK1; the disease is endometrial cancer.