TRPC4 and cancer: Although previous studies have provided evidence of the involvement of various isoforms of TRPC, such as TRPC1, TRPC4, TRPC5 and TRPC6, in regulating pathophysiological processes related to tumour metastasis [79,80,81,82,83], and several reviews [84,85,86,87] have also discussed it, current studies focus mainly on the role of TRPC6/Ca2+ signalling in cancer metastasis at the global level in various types of cancers and revealed the emerging roles of TRPC3 in melanoma metastasis at the local level.