MCOLN1 and cancer: An increased expression of transient receptor potential mucolipin1 (TRPML1) was also detected in advanced stages (III–IV) compared to early stages (I–II) of tumourigenesis in patients with non-small-cell lung cancer (NSCLC); TRPML1 silencing or inhibition in vitro impaired pathophysiological processes related to metastatic NSCLC cancer, indicating that enhanced expression of mucolipin 1 was involved in cancer progression and metastasis by promoting cell invasion, proliferation and migration in NSCLC [35].