Although previous studies have provided evidence of the involvement of various isoforms of TRPC, such as TRPC1, TRPC4, TRPC5 and TRPC6, in regulating pathophysiological processes related to tumour metastasis [79,80,81,82,83], and several reviews [84,85,86,87] have also discussed it, current studies focus mainly on the role of TRPC6/Ca2+ signalling in cancer metastasis at the global level in various types of cancers and revealed the emerging roles of TRPC3 in melanoma metastasis at the local level. The gene discussed is TRPC1; the disease is cancer.