AKT1 and gastric cancer: It was shown that calcium/calmodulin-dependent protein kinase II (CaMKII) triggered gastric cancer cell metastasis by activating nuclear factor-κB (NF-κB) signalling involving AKT, which ultimately enhanced MMP-9production in BGC-803 cells (an in vitro model of human gastric cancer) [137]; this is a metastatic prompting protein present in various cancer subtypes.