TRPV4/Ca2+ signalling enhances gastric cancer progression in an in vitro model of gastric cancer (HGC-27 and MGC-803 cells) and is significantly correlated with aggressive features (involving depth of tumour invasion and lymph node metastasis) in gastric cancer patients, which suggests its clinical utility as a biomarker to predict the prognosis in patients with gastric cancer [108]. The gene discussed is TRPV4; the disease is gastric cancer.