VHL and colorectal cancer: Proagniogenic miRNAs include, for example, miR494 targeting PTEN (phosphatase and tensin homolog deleted on chromosome ten) in lung cancer [38] or miR -155 targeting VHL (Von Hippel–Lindau tumor suppressor) in breast cancer [39], in turn, miR622 has an anti-angiogenic effect through by suppressing the CXCR4-VEGFA axis in colorectal cancer [40].