APOE and Alzheimer disease: Population-based studies have shown a weak association between the ApoE ε4 polymorphism and AD among African-Americans, (ε4/ε4, OR: 5.7, 95% CI: 2.3–14.1) and Hispanic (ε4/ε4, OR: 2.2, 95% CI: 0.7–6.7) populations, compared with Japanese (ε4/ε4, OR: 33.1, 95% CI: 13.6–80.5) and non-Hispanic persons (ε4/ε4, OR: 12.5, 95% CI: 8.8–17.7) [10].