CD274 and diffuse large B-cell lymphoma: Godfrey et al. showed that 27% of DLBCL patients (especially from the nongerminal centre subgroup) presented a PD-L1 amplification associated with inferior PFS following front-line chemoimmunotherapy [58,71,72,74,76,77,78]; this was more often detected in de-novo than transformed cases [65,76].