NOS3 and endothelial dysfunction: Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase, ameliorates vascular endothelial dysfunction by mediating endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) and scavenging oxidative stress levels, which are reportedly related to CRIF1 deletion-induced endothelial dysfunction [17].