CD4 and neoplasm: Results observed in a patient with poor prognosis (Pt.3: lower percentage of non-cytotoxic T cells, higher of NK/T cells) were consistent with previous reports; indeed, an elevated CD4/CD8 ratio is predictive of recurrence-free survival [29], while overstimulation of NK/T cells, a subpopulation lying at the interface between the innate and adaptive immune system, can induce anergy and determine a switch toward an immunosuppressive phenotype, facilitating tumor progression and immune escape [42].