Indeed, HCC lesions show an enrichment in Tregs, while CD8+ T cells are restricted to borders of tumors [27]; moreover, CD8+ T cells in HCC are dysfunctional, and both CD4 and CD8 lymphocytes have an increased expression of the inhibitory receptor TIM-3 and are replicative senescent [33]. Here, CD4 is linked to hepatocellular carcinoma.