PDCD1 and melanoma: Also, FTO has an oncogenic role and decreases the immunotherapeutic response in melanoma, by m6A demethylation of specific mRNAs such as Programmed cell death protein 1 (PD1), CXC motif Chemokine Receptor 4 (CXCR4) and SRY-Box Transcription Factor 1 (SOX1) [126].