Studies in a number of glioma cell lines have reported that the expression of xCT and the regulatory subunit 4F2hc causes glutamate release, which can activate glutamate receptors, such as the ionotropic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor, in an autocrine or paracrine manner, causing glioma cell invasion and peritumoral excitotoxic neuronal cell loss [17]. Here, SLC3A2 is linked to central nervous system cancer.