Scoring of CCL21 around the vessel perimeter in non-dilated HEVs in LNs from patients with DCIS compared to highly dilated HEVs in patients with IDCmet− and IDCmet+, revealed that a high proportion of the highly dilated HEVs in IDCs showed partial or complete loss of vessel-lining CCL21 (Figure 3A,B). This evidence concerns the gene CCL21 and ductal breast carcinoma in situ.