Moreover, Dardalhon et al. suggested that the interaction of MDSC-expressed Gal-9 and TIM-3 on Treg might drive MDSC expansion and suppressive activity [120], whereas a blockade of TIM-3 restored anti-tumor immunity by decreasing Treg numbers, their inhibitory capacity, and MDSC-mediated T cell inhibition [188]. This evidence concerns the gene HAVCR2 and neoplasm.