LPL and obesity due to melanocortin 4 receptor deficiency: LPL is responsible for catalyzing lipolysis of triglycerides in lipoproteins, as very low-density lipoproteins (VLDL), providing free fatty acids (FFAs) which are used for lipid storage, suggesting a role for LPL in initiation and development of obesity, becoming a marker for adipocyte differentiation [40].