EPHB2 and breast carcinoma: However, EphB2’s role in the different stages of breast cancer is not explicit and a model to resolve this has been suggested, i.e., in non-invasive cells, EphB2 stimulates autophagy, which triggers apoptosis, but when apoptosis is blocked in cancer cells, autophagy has a prosurvival role instead, leading to the promotion of invasion [62].