In order to establish the link between this decreased EphA1 expression and increased invasiveness, EphA1 was knocked out in HRT18 colorectal cancer cells using the CRISPR-Cas9 genome editing system, resulting in increased spreading and adhesion of the cancer cells, which suggests that EphA1 may be able to suppress these processes, achieved through the deactivation of the ERK and JNK signalling pathways [63]. Here, EPHB2 is linked to colorectal cancer.