EphA6 knockdown decreased Akt and thereby the PI3K/Akt pathway, which contributes to prostate cancer progression, as well as EIF5A2, a target gene for Akt, which promotes melanoma cell invasion; this indicates that EphA6 may mediate its effects via interaction with the PI3K/Akt pathway [35,36]. Here, EPHA6 is linked to Familial prostate cancer.