IL1B and gout: Getting et al. demonstrated that natural and synthetic ligands for MC3R (γ2-MSH and synthetic agonist MTII, respectively) in a murine model of experimental gout, inhibit aggregation of chemokine C-X-C motif ligand 1 (CXCL1), polymorphonuclear cells (PMNs), and suppress production of interleukin-1 beta (IL-1β), evoked by monosodium urate crystals in the peritoneal cavity [36].