CD8A and Zika virus infectious disease: ZIKV infection also induces robust CD4+ T cell responses, characterized by the production of type 1 cytokines, IFN-γ, tumor necrosis factor-α (TNF-α), and interleukin (IL)-2, whereas CD8+ T cells contribute to the protective mechanisms against primary ZIKV infection through their specific cytotoxic activity, and upregulation of IFN-γ and TNF-α [15].