Wnt activates β-catenin and induces the formation of a complex with SP1 that binds the promoter of the Axin2 gene to activate the transcription in colon cancer [41], and Axin2 expression is quickly suppressed following dephosphorylation of LRP6 in the lipid raft by a porcupine inhibitor [40]. Here, LRP6 is linked to colonic neoplasm.