The production of adenosine via the sequential activity of CD39 and CD73 ectoenzymes participates to the generation of an immunosuppressive tumor microenvironment, and it is reported that through the expression of immune-related molecules, such as CD39 and CD73, TDEs can regulate the immune microenvironment of tumor cells and help malignant cells avoid being recognized by immune cells [67,68]. The gene discussed is ENTPD1; the disease is neoplasm.