ANG and serum lipopolysaccharide activity: Considering that Ang-(1-7) acts as a central neuropeptide controlling AVP release and the HPA axis as well as the importance of these hormones for hypotensive and inflammatory response during endotoxemia [22,23,24,25], in the present study we aimed to determine whether Ang-(1-7) can modulate systemic inflammation through the activation of humoral pathways in late phase of endotoxemia.