Similar to disruption of the AGPS axis, reduced protein expression and enzymatic activity of AADACL1 via shRNA-mediated RNA interference lowered HG and downstream alkyl-LPA levels in ovarian carcinoma cells, which correlated with diminished tumor volume in AADACL1-deficient tumors transplanted into nude mice [68]. The gene discussed is NCEH1; the disease is ovarian carcinoma.