FBLN2 and neoplasm: Fibulin-2 dysregulation is known to promote metastatic progression; mice studies have shown that Fibulin-2 is required for tissue repair following hypoxic stress [39] and is preferentially expressed in highly metastatic cells [40], while human transcriptomic studies have confirmed FBLN2 overexpression in metastatic tumours compared to the primary tumour site [41].