IL1B and CINCA syndrome: Moreover, autoinflammatory disorders such as Mediterranean fever, familial cold autoinflammatory syndrome, Muckle-Wells syndrome, neonatal onset multisystem inflammatory disease (NOMID), hyperimmunoglobulin D syndrome and adult-onset Still disease generated much interest regarding the opportunity to treat patients affected by these syndromes using IL-1 receptor antagonist (IL-1Ra) or monoclonal anti–IL-1β antibodies.